PCORI Project Page


Background: People with serious mental illness (SMI) die approximately 10–25 years earlier than the general population, irrespective of geography or race and ethnicity. Poor health behaviors are identified as the prominent contributors to preventable early mortality. As such, self-management interventions were developed to promote positive health behavior change to address these modifiable risk factors in people with SMI. Yet, after billions of dollars and decades of research dedicated to developing interventions and disseminating evidence, the mortality gap between those with SMI and the general population is increasing.

Proposed Solution to the Problem: This convening meeting will establish the Early Mortality in People with Serious Mental Illness Virtual Roundtable, a collaborative of patients, researchers, policymakers, and organizations committed to address the early mortality health disparity in people with SMI through patient-centered outcomes research (PCOR). The establishment of the Early Mortality in People with Serious Mental Illness Virtual Roundtable and the proposed activities is designed to lend itself to advancing comparative clinical effectiveness research through the following: (1) the research agenda will delineate gaps in existing interventions (e.g., most interventions solely focus on health behaviors) and gaps in PCOR approaches to healthcare (e.g., lack of integration of PCOR such as patient-identified outcomes including trauma and loneliness to address the early mortality health disparity); and (2) the strategic plan will delineate for the first time in history patient-identified (a) intervention targets, (b) research questions, and (c) outcomes for future comparative clinical effectiveness research.

This project summary can also be found here.


This program was funded through a Patient- Centered Outcomes Research Institute® (PCORI®) Eugene Washington PCORI Engagement Award (EADI 22925). 


The views, statements, and opinions presented in this work are solely the responsibility of the author(s) and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute® (PCORI®), its Board of Governors or Methodology Committee. 


Training Agenda & PowerPoint (Click to access)
Cultural humility in community-engaged research
Timeline of early mortality for people with SMI
A Timeline of the Causes of Early Mortality in People with a Diagnosis of a Serious Mental Illness